Drug interactions
Bazedoxifene + Carbamazepine
Severity: Moderate
Bazedoxifene and Carbamazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine may reduce bazedoxifene concentrations and its endometrial protective effect when used with estrogens.
What this interaction means in plain words
Bazedoxifene and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bazedoxifene belongs to Endocrine; Carbamazepine belongs to Central Nervous System.
Why it happens
Carbamazepine induces UGT enzymes, increasing bazedoxifene glucuronidation.
What to do
Monitor for abnormal vaginal bleeding or signs of reduced effect. Consider alternative therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bazedoxifene and Carbamazepine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Bazedoxifene
- Bazedoxifene + Phenobarbitone Moderate
- Bazedoxifene + Phenytoin Moderate
- Bazedoxifene + Rifampicin Moderate
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Bazedoxifene with Carbamazepine?
MediHelp rates the interaction as moderate. Bazedoxifene and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine may reduce bazedoxifene concentrations and its endometrial protective effect when used with estrogens.
How serious is the interaction between Bazedoxifene and Carbamazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for abnormal vaginal bleeding or signs of reduced effect. Consider alternative therapy if needed.
What other medicines interact with Bazedoxifene?
MediHelp also lists interactions of Bazedoxifene with, for example, Phenobarbitone, Phenytoin, Rifampicin. The full list is on the Bazedoxifene page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
