Drug interactions
Bazedoxifene / conjugated estrogens + Bosentan
Severity: Moderate
Bazedoxifene / conjugated estrogens and Bosentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may reduce estrogen concentrations through CYP3A4 induction. This could lessen control of menopausal symptoms and, in women with a uterus, reduce endometrial protection.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Bosentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Bosentan induces CYP3A4, increasing estrogen and bazedoxifene metabolism.
What to do
Monitor symptom control and watch for abnormal uterine bleeding. Adjust therapy if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Cyclosporine Contraindicated
- Bosentan + Glyburide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Bosentan?
MediHelp rates the interaction as moderate. Bazedoxifene / conjugated estrogens and Bosentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan may reduce estrogen concentrations through CYP3A4 induction. This could lessen control of menopausal symptoms and, in women with a uterus, reduce endometrial protection.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Bosentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control and watch for abnormal uterine bleeding. Adjust therapy if efficacy is lost.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.
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