Drug interactions
Bazedoxifene / conjugated estrogens + Clarithromycin
Severity: Moderate
Bazedoxifene / conjugated estrogens and Clarithromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may raise exposure to the estrogen and bazedoxifene components through CYP3A4 inhibition. This could increase estrogen-related adverse effects such as thromboembolism, breast tenderness and endometrial stimulation.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by clarithromycin reduces metabolism of the estrogen and bazedoxifene components.
What to do
Monitor for estrogenic adverse effects during a short antibiotic course; consider an alternative antibiotic if prolonged therapy is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Clarithromycin?
MediHelp rates the interaction as moderate. Bazedoxifene / conjugated estrogens and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin may raise exposure to the estrogen and bazedoxifene components through CYP3A4 inhibition. This could increase estrogen-related adverse effects such as thromboembolism, breast tenderness and endometrial stimulation.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Clarithromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic adverse effects during a short antibiotic course; consider an alternative antibiotic if prolonged therapy is needed.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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