Drug interactions
Bazedoxifene / conjugated estrogens + Clomipramine
Severity: Minor
Bazedoxifene / conjugated estrogens and Clomipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens may alter tricyclic antidepressant exposure, with reports of increased adverse effects such as sedation, anticholinergic effects and hypotension, and sometimes reduced antidepressant response. The effect is inconsistent and usually small.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Clomipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible estrogen-related inhibition of hepatic tricyclic metabolism; the mechanism is not well established.
What to do
Monitor clinical response and tricyclic adverse effects when estrogen is started or stopped. Adjust the clomipramine dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Clomipramine?
MediHelp rates the interaction as minor. Bazedoxifene / conjugated estrogens and Clomipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogens may alter tricyclic antidepressant exposure, with reports of increased adverse effects such as sedation, anticholinergic effects and hypotension, and sometimes reduced antidepressant response. The effect is inconsistent and usually small.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Clomipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and tricyclic adverse effects when estrogen is started or stopped. Adjust the clomipramine dose if needed.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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