Drug interactions
Bazedoxifene / conjugated estrogens + Dalteparin
Severity: Major
Bazedoxifene / conjugated estrogens and Dalteparin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogen-containing products increase the risk of venous thromboembolism, and bazedoxifene also carries a VTE risk. In a patient who needs dalteparin for treatment or prevention of thrombosis, this raises the underlying clotting risk the anticoagulant is meant to reduce.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Dalteparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic opposition: estrogens increase clotting factor levels and thrombotic tendency while the heparin inhibits coagulation.
What to do
Avoid the estrogen combination in patients with active or recent VTE; consider a non-hormonal alternative. If used, assess VTE risk and reassess the need regularly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Dalteparin?
MediHelp rates the interaction as major. Bazedoxifene / conjugated estrogens and Dalteparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Estrogen-containing products increase the risk of venous thromboembolism, and bazedoxifene also carries a VTE risk. In a patient who needs dalteparin for treatment or prevention of thrombosis, this raises the underlying clotting risk the anticoagulant is meant to reduce.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Dalteparin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the estrogen combination in patients with active or recent VTE; consider a non-hormonal alternative. If used, assess VTE risk and reassess the need regularly.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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