Drug interactions
Bazedoxifene / conjugated estrogens + Dronedarone
Severity: Moderate
Bazedoxifene / conjugated estrogens and Dronedarone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone may increase exposure to conjugated estrogens and bazedoxifene by inhibiting CYP3A4 and P-glycoprotein. This could increase estrogenic adverse effects, including thromboembolic risk.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein by dronedarone.
What to do
Monitor for estrogen excess such as breast tenderness or bleeding. Reassess therapy if adverse effects arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Dronedarone?
MediHelp rates the interaction as moderate. Bazedoxifene / conjugated estrogens and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone may increase exposure to conjugated estrogens and bazedoxifene by inhibiting CYP3A4 and P-glycoprotein. This could increase estrogenic adverse effects, including thromboembolic risk.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Dronedarone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogen excess such as breast tenderness or bleeding. Reassess therapy if adverse effects arise.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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