Drug interactions
Bazedoxifene-conjugated estrogens + Efavirenz
Severity: Moderate
Bazedoxifene-conjugated estrogens and Efavirenz: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz induces CYP3A4 and may lower concentrations of conjugated estrogens and bazedoxifene. This may result in reduced symptom control and reduced endometrial protection.
What this interaction means in plain words
Bazedoxifene-conjugated estrogens and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bazedoxifene-conjugated estrogens belongs to Endocrine; Efavirenz belongs to Anti Virals.
Why it happens
Efavirenz induces CYP3A4, increasing metabolic clearance of estrogens and bazedoxifene.
What to do
Monitor for return of menopausal symptoms and for breakthrough uterine bleeding. Adjust therapy or consider alternatives if efficacy is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Major
- Antithrombin iii + Bazedoxifene-conjugated estrogens Major
- Bazedoxifene-conjugated estrogens + Bemiparin Major
- Bazedoxifene-conjugated estrogens + Carbamazepine Major
Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Bazedoxifene-conjugated estrogens with Efavirenz?
MediHelp rates the interaction as moderate. Bazedoxifene-conjugated estrogens and Efavirenz can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz induces CYP3A4 and may lower concentrations of conjugated estrogens and bazedoxifene. This may result in reduced symptom control and reduced endometrial protection.
How serious is the interaction between Bazedoxifene-conjugated estrogens and Efavirenz?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for return of menopausal symptoms and for breakthrough uterine bleeding. Adjust therapy or consider alternatives if efficacy is inadequate.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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