Drug interactions
Bazedoxifene / conjugated estrogens + Fluconazole
Severity: Moderate
Bazedoxifene / conjugated estrogens and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole may increase exposure to the estrogen component through CYP3A4 inhibition. This may lead to more estrogenic adverse effects such as breast tenderness, nausea, headache and bleeding.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated estrogen metabolism by fluconazole.
What to do
Monitor for estrogen-related adverse effects and reduce the dose if they appear. Reassess when fluconazole is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Fluconazole?
MediHelp rates the interaction as moderate. Bazedoxifene / conjugated estrogens and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole may increase exposure to the estrogen component through CYP3A4 inhibition. This may lead to more estrogenic adverse effects such as breast tenderness, nausea, headache and bleeding.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogen-related adverse effects and reduce the dose if they appear. Reassess when fluconazole is stopped.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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