Drug reference
fluconazole
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Anti Fungals (Azoles)
Mechanism of action
Highly selective inhibitor of fungal cytochrome P-450-dependent enzyme lanosterol 14-alpha-demethylase Subsequent loss of normal sterols correlates with accumulation of 14 alpha-methyl sterols in fungi and may be responsible for the fungistatic activity of fluconazole
Common side effects
- Rash
- Vomiting
- Headache
- Nausea
- QT prolongation
- Abdominal pain
- Diarrhea
Known interactions (37)
- dronedarone + fluconazole Contraindicated
- erythromycin + fluconazole Contraindicated
- flibanserin + fluconazole Contraindicated
- fluconazole + pimozide Contraindicated
- fluconazole + quinidine Contraindicated
- bendamustine + fluconazole Major
- buprenorphine + fluconazole Major
- Citalopram + fluconazole Major
- clozapine + fluconazole Major
- colchicine + fluconazole Major
- ergotamine + fluconazole Major
- fluconazole + indapamide Major
- fluconazole + ketoconazole Major
- fluconazole + lovastatin Major
- fluconazole + methadone Major
- fluconazole + Moxifloxacin Major
- fluconazole + phenytoin Major
- fluconazole + ribociclib Major
- fluconazole + simvastatin Major
- fluconazole + sirolimus Major
- fluconazole + sunitinib Major
- fluconazole + tacrolimus Major
- fluconazole + tolvaptan Major
- fluconazole + warfarin Major
- alfuzosin + fluconazole Moderate
- aripiprazole + fluconazole Moderate
- asenapine + fluconazole Moderate
- ethinyl estradiol/gestodene + fluconazole Moderate
- Ethinylestradiol and Cyproterone Acetate + fluconazole Moderate
- everolimus + fluconazole Moderate
- fluconazole + levofloxacin Moderate
- fluconazole + Metronidazole Moderate
- fluconazole + prednisolone Moderate
- fluconazole + ranolazine Moderate
- fluconazole + rosuvastatin Moderate
- fluconazole + silodosin Moderate
- fluconazole + solifenacin Moderate
Related conditions
Frequently asked questions
What drug class is fluconazole?
fluconazole belongs to: Anti Fungals.
How does fluconazole work?
Highly selective inhibitor of fungal cytochrome P-450-dependent enzyme lanosterol 14-alpha-demethylase Subsequent loss of normal sterols correlates with accumulation of 14 alpha-methyl sterols in fungi and may be responsible for the fungistatic activity of fluconazole
What are the common side effects of fluconazole?
Rash, Vomiting, Headache, Nausea, QT prolongation, Abdominal pain, Diarrhea
Which drugs interact with fluconazole?
dronedarone, erythromycin, flibanserin, pimozide, quinidine, bendamustine, buprenorphine, Citalopram, clozapine, colchicine, ergotamine, indapamide, ketoconazole, lovastatin, methadone
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