Drug interactions
Bazedoxifene-conjugated estrogens + Griseofulvin
Severity: Moderate
Bazedoxifene-conjugated estrogens and Griseofulvin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin is a CYP3A4 inducer that can lower circulating estrogen and bazedoxifene concentrations. This may reduce endometrial protection from bazedoxifene and diminish relief of menopausal symptoms, and breakthrough bleeding has been reported with other estrogen products.
What this interaction means in plain words
Bazedoxifene-conjugated estrogens and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bazedoxifene-conjugated estrogens belongs to Endocrine; Griseofulvin belongs to Anti Fungals.
Why it happens
Induction of hepatic CYP3A4 by griseofulvin increases metabolism of estrogens and bazedoxifene.
What to do
Monitor for loss of symptom control and unexpected vaginal bleeding, and evaluate any bleeding appropriately. Consider an alternative antifungal if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Major
- Antithrombin iii + Bazedoxifene-conjugated estrogens Major
- Bazedoxifene-conjugated estrogens + Bemiparin Major
- Bazedoxifene-conjugated estrogens + Carbamazepine Major
Other interactions of Griseofulvin
Frequently asked questions
Can I take Bazedoxifene-conjugated estrogens with Griseofulvin?
MediHelp rates the interaction as moderate. Bazedoxifene-conjugated estrogens and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Griseofulvin is a CYP3A4 inducer that can lower circulating estrogen and bazedoxifene concentrations. This may reduce endometrial protection from bazedoxifene and diminish relief of menopausal symptoms, and breakthrough bleeding has been reported with other estrogen products.
How serious is the interaction between Bazedoxifene-conjugated estrogens and Griseofulvin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of symptom control and unexpected vaginal bleeding, and evaluate any bleeding appropriately. Consider an alternative antifungal if feasible.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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