Drug interactions
Bazedoxifene-conjugated estrogens + Imipramine
Severity: Minor
Bazedoxifene-conjugated estrogens and Imipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens can increase imipramine concentrations, with greater sedation, anticholinergic effects and cardiac toxicity possible. Case reports exist but the effect is inconsistent.
What this interaction means in plain words
Bazedoxifene-conjugated estrogens and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bazedoxifene-conjugated estrogens belongs to Endocrine; Imipramine belongs to Central Nervous System.
Why it happens
Possible estrogen-mediated inhibition of tricyclic metabolism; mechanism not firmly established.
What to do
Monitor for imipramine toxicity and response when estrogen is started or stopped, and adjust the dose accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Major
- Antithrombin iii + Bazedoxifene-conjugated estrogens Major
- Bazedoxifene-conjugated estrogens + Bemiparin Major
- Bazedoxifene-conjugated estrogens + Carbamazepine Major
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Bazedoxifene-conjugated estrogens with Imipramine?
MediHelp rates the interaction as minor. Bazedoxifene-conjugated estrogens and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogens can increase imipramine concentrations, with greater sedation, anticholinergic effects and cardiac toxicity possible. Case reports exist but the effect is inconsistent.
How serious is the interaction between Bazedoxifene-conjugated estrogens and Imipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for imipramine toxicity and response when estrogen is started or stopped, and adjust the dose accordingly.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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