Drug interactions
Bazedoxifene / conjugated estrogens + Itraconazole
Severity: Moderate
Bazedoxifene / conjugated estrogens and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may raise exposure to the estrogen and bazedoxifene components, which could increase estrogen-related adverse effects such as thromboembolism and endometrial stimulation.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Itraconazole inhibits CYP3A4, reducing metabolism of estrogens and bazedoxifene.
What to do
Monitor for estrogenic adverse effects such as breast tenderness, bleeding and thrombotic symptoms. Consider an alternative antifungal or a dose review if effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bazedoxifene / conjugated estrogens and Itraconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Itraconazole?
MediHelp rates the interaction as moderate. Bazedoxifene / conjugated estrogens and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole may raise exposure to the estrogen and bazedoxifene components, which could increase estrogen-related adverse effects such as thromboembolism and endometrial stimulation.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic adverse effects such as breast tenderness, bleeding and thrombotic symptoms. Consider an alternative antifungal or a dose review if effects occur.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
