Drug interactions
Bazedoxifene-conjugated estrogens + Ketoconazole
Severity: Moderate
Bazedoxifene-conjugated estrogens and Ketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole is a strong CYP3A4 inhibitor and may considerably raise exposure to the estrogens and bazedoxifene. This could increase estrogen-related adverse effects, including thromboembolic events and endometrial effects.
What this interaction means in plain words
Bazedoxifene-conjugated estrogens and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bazedoxifene-conjugated estrogens belongs to Endocrine; Ketoconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition by ketoconazole decreases metabolic clearance of estrogens and bazedoxifene.
What to do
Use an alternative antifungal if possible. If coadministered, monitor for estrogen excess effects and review the need for therapy during prolonged azole courses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Major
- Antithrombin iii + Bazedoxifene-conjugated estrogens Major
- Bazedoxifene-conjugated estrogens + Bemiparin Major
- Bazedoxifene-conjugated estrogens + Carbamazepine Major
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Bazedoxifene-conjugated estrogens with Ketoconazole?
MediHelp rates the interaction as moderate. Bazedoxifene-conjugated estrogens and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole is a strong CYP3A4 inhibitor and may considerably raise exposure to the estrogens and bazedoxifene. This could increase estrogen-related adverse effects, including thromboembolic events and endometrial effects.
How serious is the interaction between Bazedoxifene-conjugated estrogens and Ketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antifungal if possible. If coadministered, monitor for estrogen excess effects and review the need for therapy during prolonged azole courses.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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