Drug interactions
Bazedoxifene / conjugated estrogens + Moxifloxacin
Severity: Minor
Bazedoxifene / conjugated estrogens and Moxifloxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotic effects on gut flora were once thought to lower oral estrogen levels by reducing enterohepatic recycling. Controlled data for non-rifamycin antibiotics show no meaningful reduction in hormone exposure, and this combination is not expected to have clinical relevance.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Moxifloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction of enterohepatic recirculation of estrogens by altered gut flora, which is not shown for fluoroquinolones.
What to do
No dose adjustment is needed. Be aware of the theoretical effect only if breakthrough bleeding or loss of estrogenic effect occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Moxifloxacin?
MediHelp rates the interaction as minor. Bazedoxifene / conjugated estrogens and Moxifloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotic effects on gut flora were once thought to lower oral estrogen levels by reducing enterohepatic recycling. Controlled data for non-rifamycin antibiotics show no meaningful reduction in hormone exposure, and this combination is not expected to have clinical relevance.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Moxifloxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Be aware of the theoretical effect only if breakthrough bleeding or loss of estrogenic effect occurs.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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