Drug interactions
Bazedoxifene / conjugated estrogens + Nilutamide
Severity: Minor
Bazedoxifene / conjugated estrogens and Nilutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilutamide may increase exposure to estrogens and bazedoxifene metabolized by CYP3A4. This might increase estrogenic adverse effects. The combination is unusual clinically.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Nilutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of CYP3A4 metabolism of the estrogen and bazedoxifene components.
What to do
No routine adjustment; monitor for estrogen-related adverse effects such as breast tenderness or bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nilutamide
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Nilutamide?
MediHelp rates the interaction as minor. Bazedoxifene / conjugated estrogens and Nilutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nilutamide may increase exposure to estrogens and bazedoxifene metabolized by CYP3A4. This might increase estrogenic adverse effects. The combination is unusual clinically.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Nilutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor for estrogen-related adverse effects such as breast tenderness or bleeding.
What other medicines interact with Nilutamide?
MediHelp also lists interactions of Nilutamide with, for example, Dihydroergotamine intranasal, Mavacamten, Artemether / lumefantrine. The full list is on the Nilutamide page.
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