Drug interactions
Bazedoxifene / conjugated estrogens + Nitrofurantoin
Severity: Minor
Bazedoxifene / conjugated estrogens and Nitrofurantoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitrofurantoin is not an enzyme inducer and has no well-established effect on estrogen levels. The claimed mechanism of altered gut flora lowering hormone exposure is not supported for this antibiotic.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Nitrofurantoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established mechanism; a theoretical effect on enterohepatic recycling of estrogens has not been shown for nitrofurantoin.
What to do
No action is required. Counsel patients to report unexpected bleeding or return of menopausal symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nitrofurantoin
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Nitrofurantoin?
MediHelp rates the interaction as minor. Bazedoxifene / conjugated estrogens and Nitrofurantoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nitrofurantoin is not an enzyme inducer and has no well-established effect on estrogen levels. The claimed mechanism of altered gut flora lowering hormone exposure is not supported for this antibiotic.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Nitrofurantoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is required. Counsel patients to report unexpected bleeding or return of menopausal symptoms.
What other medicines interact with Nitrofurantoin?
MediHelp also lists interactions of Nitrofurantoin with, for example, Pexidartinib, Pretomanid, Aluminum hydroxide. The full list is on the Nitrofurantoin page.
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