Drug interactions
Nitrofurantoin + Pretomanid
Severity: Major
Nitrofurantoin and Pretomanid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The pretomanid regimen is associated with hepatotoxicity, and nitrofurantoin can cause liver injury, so combined use may increase the risk of liver damage. Peripheral neuropathy is also a concern with both agents.
What this interaction means in plain words
Nitrofurantoin and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nitrofurantoin belongs to Anti Bacterial; Pretomanid belongs to Anti Bacterial.
Why it happens
Additive pharmacodynamic hepatotoxicity and neurotoxicity.
What to do
Avoid nitrofurantoin during pretomanid therapy and use another urinary agent. If it cannot be avoided, monitor liver function and neurologic symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nitrofurantoin and Pretomanid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Nitrofurantoin
- Nitrofurantoin + Pexidartinib Major
- Aluminum hydroxide + Nitrofurantoin Moderate
- Bupivacaine implant + Nitrofurantoin Moderate
- Calcium carbonate + Nitrofurantoin Moderate
- Cholera vaccine + Nitrofurantoin Moderate
- Dapsone + Nitrofurantoin Moderate
Other interactions of Pretomanid
Frequently asked questions
Can I take Nitrofurantoin with Pretomanid?
MediHelp rates the interaction as major. Nitrofurantoin and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The pretomanid regimen is associated with hepatotoxicity, and nitrofurantoin can cause liver injury, so combined use may increase the risk of liver damage. Peripheral neuropathy is also a concern with both agents.
How serious is the interaction between Nitrofurantoin and Pretomanid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid nitrofurantoin during pretomanid therapy and use another urinary agent. If it cannot be avoided, monitor liver function and neurologic symptoms.
What other medicines interact with Nitrofurantoin?
MediHelp also lists interactions of Nitrofurantoin with, for example, Pexidartinib, Aluminum hydroxide, Bupivacaine implant. The full list is on the Nitrofurantoin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
