Drug interactions
Nitrofurantoin + Pexidartinib
Severity: Major
Nitrofurantoin and Pexidartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib carries a boxed warning for serious liver injury, and nitrofurantoin can also cause hepatotoxicity, including hepatitis. Concurrent use may add to the risk of liver damage.
What this interaction means in plain words
Nitrofurantoin and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nitrofurantoin belongs to Anti Bacterial; Pexidartinib belongs to Oncology.
Why it happens
Additive pharmacodynamic hepatotoxicity.
What to do
Use an alternative antibiotic where possible. If both are needed, check liver tests before and regularly during treatment and stop for liver injury.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nitrofurantoin
- Nitrofurantoin + Pretomanid Major
- Aluminum hydroxide + Nitrofurantoin Moderate
- Bupivacaine implant + Nitrofurantoin Moderate
- Calcium carbonate + Nitrofurantoin Moderate
- Cholera vaccine + Nitrofurantoin Moderate
- Dapsone + Nitrofurantoin Moderate
Other interactions of Pexidartinib
Frequently asked questions
Can I take Nitrofurantoin with Pexidartinib?
MediHelp rates the interaction as major. Nitrofurantoin and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib carries a boxed warning for serious liver injury, and nitrofurantoin can also cause hepatotoxicity, including hepatitis. Concurrent use may add to the risk of liver damage.
How serious is the interaction between Nitrofurantoin and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic where possible. If both are needed, check liver tests before and regularly during treatment and stop for liver injury.
What other medicines interact with Nitrofurantoin?
MediHelp also lists interactions of Nitrofurantoin with, for example, Pretomanid, Aluminum hydroxide, Bupivacaine implant. The full list is on the Nitrofurantoin page.
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