Drug interactions
Bazedoxifene-conjugated estrogens + Oxcarbazepine
Severity: Moderate
Bazedoxifene-conjugated estrogens and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine is a weak-to-moderate inducer of CYP3A4 and may lower exposure to estrogens and bazedoxifene. Reduced estrogen effect can lead to return of menopausal symptoms, and reduced bazedoxifene exposure may weaken endometrial protection.
What this interaction means in plain words
Bazedoxifene-conjugated estrogens and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bazedoxifene-conjugated estrogens belongs to Endocrine; Oxcarbazepine belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 (and possibly UGT) increases the metabolic clearance of estrogens and bazedoxifene.
What to do
Monitor for recurrent vasomotor symptoms and abnormal uterine bleeding, and evaluate the endometrium if bleeding occurs. Consider an alternative anticonvulsant or a different menopausal therapy if the combination is not effective.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Major
- Antithrombin iii + Bazedoxifene-conjugated estrogens Major
- Bazedoxifene-conjugated estrogens + Bemiparin Major
- Bazedoxifene-conjugated estrogens + Carbamazepine Major
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Bazedoxifene-conjugated estrogens with Oxcarbazepine?
MediHelp rates the interaction as moderate. Bazedoxifene-conjugated estrogens and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine is a weak-to-moderate inducer of CYP3A4 and may lower exposure to estrogens and bazedoxifene. Reduced estrogen effect can lead to return of menopausal symptoms, and reduced bazedoxifene exposure may weaken endometrial protection.
How serious is the interaction between Bazedoxifene-conjugated estrogens and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for recurrent vasomotor symptoms and abnormal uterine bleeding, and evaluate the endometrium if bleeding occurs. Consider an alternative anticonvulsant or a different menopausal therapy if the combination is not effective.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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