Drug interactions
Bazedoxifene-conjugated estrogens + Primidone
Severity: Moderate
Bazedoxifene-conjugated estrogens and Primidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is metabolized to phenobarbital and acts as an enzyme inducer, which can lower exposure to estrogens and bazedoxifene. Reduced bazedoxifene exposure may weaken endometrial protection, and estrogen effect may decline.
What this interaction means in plain words
Bazedoxifene-conjugated estrogens and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bazedoxifene-conjugated estrogens belongs to Endocrine; Primidone belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 and glucuronidation by primidone and its phenobarbital metabolite increases clearance of the components.
What to do
Monitor for loss of symptom control and for abnormal uterine bleeding, and evaluate the endometrium if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Major
- Antithrombin iii + Bazedoxifene-conjugated estrogens Major
- Bazedoxifene-conjugated estrogens + Bemiparin Major
- Bazedoxifene-conjugated estrogens + Carbamazepine Major
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Bazedoxifene-conjugated estrogens with Primidone?
MediHelp rates the interaction as moderate. Bazedoxifene-conjugated estrogens and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone is metabolized to phenobarbital and acts as an enzyme inducer, which can lower exposure to estrogens and bazedoxifene. Reduced bazedoxifene exposure may weaken endometrial protection, and estrogen effect may decline.
How serious is the interaction between Bazedoxifene-conjugated estrogens and Primidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of symptom control and for abnormal uterine bleeding, and evaluate the endometrium if bleeding occurs.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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