Drug interactions
Bazedoxifene / conjugated estrogens + Sirolimus
Severity: Minor
Bazedoxifene / conjugated estrogens and Sirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus may inhibit P-glycoprotein, which could slightly raise estrogen or bazedoxifene exposure. The clinical significance is likely small.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible P-gp inhibition by sirolimus reducing efflux of the estrogen components.
What to do
No routine adjustment is needed. Review estrogenic adverse effects and thrombotic risk factors as part of regular follow-up.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bazedoxifene / conjugated estrogens and Sirolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Sirolimus?
MediHelp rates the interaction as minor. Bazedoxifene / conjugated estrogens and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sirolimus may inhibit P-glycoprotein, which could slightly raise estrogen or bazedoxifene exposure. The clinical significance is likely small.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Sirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Review estrogenic adverse effects and thrombotic risk factors as part of regular follow-up.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
