Drug interactions
Bazedoxifene / conjugated estrogens + Tacrolimus
Severity: Minor
Bazedoxifene / conjugated estrogens and Tacrolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus may inhibit P-glycoprotein and potentially raise levels of bazedoxifene. The clinical significance is uncertain and likely small.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible P-glycoprotein inhibition by tacrolimus reducing efflux of bazedoxifene.
What to do
No routine adjustment is needed; monitor for estrogenic adverse effects such as thromboembolic events.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Tacrolimus?
MediHelp rates the interaction as minor. Bazedoxifene / conjugated estrogens and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tacrolimus may inhibit P-glycoprotein and potentially raise levels of bazedoxifene. The clinical significance is uncertain and likely small.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Tacrolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for estrogenic adverse effects such as thromboembolic events.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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