Drug interactions
Bcg vaccine live + Moxifloxacin
Severity: Moderate
Bcg vaccine live and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live BCG vaccine depends on replication of viable bacteria to induce immunity. Concurrent antibacterial therapy may reduce the vaccine's effectiveness, although moxifloxacin does have antimycobacterial activity.
What this interaction means in plain words
Bcg vaccine live and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity may inhibit replication of the live attenuated organism, impairing immunization.
What to do
Postpone BCG vaccination until the antibiotic course is complete, or consider revaccination if given during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Bcg vaccine live with Moxifloxacin?
MediHelp rates the interaction as moderate. Bcg vaccine live and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Live BCG vaccine depends on replication of viable bacteria to induce immunity. Concurrent antibacterial therapy may reduce the vaccine's effectiveness, although moxifloxacin does have antimycobacterial activity.
How serious is the interaction between Bcg vaccine live and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Postpone BCG vaccination until the antibiotic course is complete, or consider revaccination if given during treatment.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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