Drug interactions
Bcg vaccine live + Upadacitinib
Severity: Contraindicated
Bcg vaccine live and Upadacitinib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Upadacitinib-induced immunosuppression raises the risk of disseminated BCG infection after a live BCG vaccine. The vaccine response may also be reduced.
What this interaction means in plain words
Bcg vaccine live and Upadacitinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Immunosuppression impairs control of live attenuated mycobacteria.
What to do
Avoid live BCG vaccination during upadacitinib treatment. Complete needed vaccination before starting therapy, allowing at least 4 weeks.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Cyclosporine + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Upadacitinib Contraindicated
Frequently asked questions
Can I take Bcg vaccine live with Upadacitinib?
MediHelp rates the interaction as contraindicated. Bcg vaccine live and Upadacitinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Upadacitinib-induced immunosuppression raises the risk of disseminated BCG infection after a live BCG vaccine. The vaccine response may also be reduced.
How serious is the interaction between Bcg vaccine live and Upadacitinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live BCG vaccination during upadacitinib treatment. Complete needed vaccination before starting therapy, allowing at least 4 weeks.
What other medicines interact with Upadacitinib?
MediHelp also lists interactions of Upadacitinib with, for example, Abrocitinib, Adenovirus types 4 and 7 live, Baricitinib. The full list is on the Upadacitinib page.
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