Drug reference
upadacitinib
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Musculoskeletal (DMARDs)
Mechanism of action
Janus kinase-1 (JAK1)-selective inhibitor; JAK1 is essential for certain cytokines to elicit signals from various interleukins, cardiotrophin, neurotrophin, and interferons. These signals are crucial in maintaining the inflammatory condition in rheumatoid arthritis (RA); inhibition of JAK reduces production of and modulates proinflammatory cytokines central to RA
Common side effects
- Neutropenia
- Nausea
- Cough
- Lymphopenia
- Pyrexia
- Elevated AST
- Elevated ALT
Known interactions (13)
- baricitinib + upadacitinib Contraindicated
- abatacept + upadacitinib Major
- adalimumab + upadacitinib Major
- anti-thymocyte + upadacitinib Major
- azathioprine + upadacitinib Major
- basiliximab + upadacitinib Major
- certolizumab pegol + upadacitinib Major
- cyclosporin + upadacitinib Major
- etanercept + upadacitinib Major
- fingolimod + upadacitinib Major
- golimumab + upadacitinib Major
- guselkumab + upadacitinib Major
- infliximab + upadacitinib Major
Related conditions
Frequently asked questions
What drug class is upadacitinib?
upadacitinib belongs to: Musculoskeletal.
How does upadacitinib work?
Janus kinase-1 (JAK1)-selective inhibitor; JAK1 is essential for certain cytokines to elicit signals from various interleukins, cardiotrophin, neurotrophin, and interferons. These signals are crucial in maintaining the inflammatory condition in rheumatoid arthritis (RA); inhibition of JAK reduces production of and modulates proinflammatory cytokines central to RA
What are the common side effects of upadacitinib?
Neutropenia, Nausea, Cough, Lymphopenia, Pyrexia, Elevated AST, Elevated ALT
Which drugs interact with upadacitinib?
baricitinib, abatacept, adalimumab, anti-thymocyte, azathioprine, basiliximab, certolizumab pegol, cyclosporin, etanercept, fingolimod, golimumab, guselkumab, infliximab
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