Drug interactions
Dengue vaccine + Upadacitinib
Severity: Contraindicated
Dengue vaccine and Upadacitinib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The dengue vaccine is live attenuated, and immunosuppression from upadacitinib may allow uncontrolled vaccine virus replication. The immune response may also be inadequate.
What this interaction means in plain words
Dengue vaccine and Upadacitinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Immunosuppression impairs control of live attenuated virus and reduces vaccine response.
What to do
Avoid the live dengue vaccine during upadacitinib treatment. Vaccinate before starting therapy where indicated.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Cyclosporine + Upadacitinib Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Upadacitinib Contraindicated
Frequently asked questions
Can I take Dengue vaccine with Upadacitinib?
MediHelp rates the interaction as contraindicated. Dengue vaccine and Upadacitinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The dengue vaccine is live attenuated, and immunosuppression from upadacitinib may allow uncontrolled vaccine virus replication. The immune response may also be inadequate.
How serious is the interaction between Dengue vaccine and Upadacitinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the live dengue vaccine during upadacitinib treatment. Vaccinate before starting therapy where indicated.
What other medicines interact with Upadacitinib?
MediHelp also lists interactions of Upadacitinib with, for example, Abrocitinib, Adenovirus types 4 and 7 live, Baricitinib. The full list is on the Upadacitinib page.
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