Drug interactions
Influenza virus vaccine quadrivalent intranasal + Upadacitinib
Severity: Contraindicated
Influenza virus vaccine quadrivalent intranasal and Upadacitinib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The intranasal influenza vaccine is live attenuated, and upadacitinib-related immunosuppression may permit vaccine virus replication and illness. The vaccine response may also be reduced.
What this interaction means in plain words
Influenza virus vaccine quadrivalent intranasal and Upadacitinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Immunosuppression impairs control of live attenuated virus.
What to do
Use an inactivated injectable influenza vaccine instead during upadacitinib therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Cyclosporine + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent intranasal with Upadacitinib?
MediHelp rates the interaction as contraindicated. Influenza virus vaccine quadrivalent intranasal and Upadacitinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The intranasal influenza vaccine is live attenuated, and upadacitinib-related immunosuppression may permit vaccine virus replication and illness. The vaccine response may also be reduced.
How serious is the interaction between Influenza virus vaccine quadrivalent intranasal and Upadacitinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an inactivated injectable influenza vaccine instead during upadacitinib therapy.
What other medicines interact with Upadacitinib?
MediHelp also lists interactions of Upadacitinib with, for example, Abrocitinib, Adenovirus types 4 and 7 live, Baricitinib. The full list is on the Upadacitinib page.
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