Drug interactions
Bedaquiline + Indapamide
Severity: Major
Bedaquiline and Indapamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bedaquiline prolongs the QT interval, and indapamide can also contribute to QT prolongation, mainly through hypokalemia and hypomagnesemia. Together they increase the risk of torsades de pointes.
What this interaction means in plain words
Bedaquiline and Indapamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bedaquiline belongs to Anti Bacterial; Indapamide belongs to Cardiovascular.
Why it happens
Additive QTc prolongation, with diuretic-induced electrolyte depletion increasing arrhythmia susceptibility.
What to do
Obtain baseline and periodic ECGs and keep potassium, magnesium and calcium within normal range. Consider an alternative diuretic if QTc becomes excessively prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indapamide
Other interactions of Bedaquiline
- Bedaquiline + Ziprasidone Contraindicated
- Alfuzosin + Bedaquiline Major
- Amiodarone + Bedaquiline Major
- Amisulpride + Bedaquiline Major
- Amitriptyline + Bedaquiline Major
- Amobarbital + Bedaquiline Major
Frequently asked questions
Can I take Bedaquiline with Indapamide?
MediHelp rates the interaction as major. Bedaquiline and Indapamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bedaquiline prolongs the QT interval, and indapamide can also contribute to QT prolongation, mainly through hypokalemia and hypomagnesemia. Together they increase the risk of torsades de pointes.
How serious is the interaction between Bedaquiline and Indapamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline and periodic ECGs and keep potassium, magnesium and calcium within normal range. Consider an alternative diuretic if QTc becomes excessively prolonged.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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