Drug interactions
Amiodarone + Bedaquiline
Severity: Major
Amiodarone and Bedaquiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and amiodarone has a very long half-life so its effect persists after discontinuation. Combined use raises the risk of torsades de pointes and other serious ventricular arrhythmias.
What this interaction means in plain words
Amiodarone and Bedaquiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Bedaquiline belongs to Anti Bacterial.
Why it happens
Additive QTc prolongation through pharmacodynamic effects on cardiac repolarization.
What to do
Avoid the combination where an alternative exists; if essential, obtain a baseline ECG and repeat it regularly, and keep potassium, magnesium and calcium within normal ranges. Stop bedaquiline if significant QTc prolongation or ventricular arrhythmia develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Bedaquiline
- Bedaquiline + Ziprasidone Contraindicated
- Alfuzosin + Bedaquiline Major
- Amisulpride + Bedaquiline Major
- Amitriptyline + Bedaquiline Major
- Amobarbital + Bedaquiline Major
- Anagrelide + Bedaquiline Major
Frequently asked questions
Can I take Amiodarone with Bedaquiline?
MediHelp rates the interaction as major. Amiodarone and Bedaquiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, and amiodarone has a very long half-life so its effect persists after discontinuation. Combined use raises the risk of torsades de pointes and other serious ventricular arrhythmias.
How serious is the interaction between Amiodarone and Bedaquiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative exists; if essential, obtain a baseline ECG and repeat it regularly, and keep potassium, magnesium and calcium within normal ranges. Stop bedaquiline if significant QTc prolongation or ventricular arrhythmia develops.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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