Drug interactions
Amisulpride + Bedaquiline
Severity: Major
Amisulpride and Bedaquiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bedaquiline prolongs the QT interval, and amisulpride has a similar dose-related effect. Together they increase the possibility of serious ventricular arrhythmia, particularly given the long half-life of bedaquiline.
What this interaction means in plain words
Amisulpride and Bedaquiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Bedaquiline belongs to Anti Bacterial.
Why it happens
Additive QT prolongation through effects on cardiac repolarization.
What to do
Avoid if an alternative is available. Otherwise obtain a baseline ECG, monitor QTc regularly, and keep potassium, magnesium and calcium within normal ranges.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amisulpride and Bedaquiline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Bedaquiline
- Bedaquiline + Ziprasidone Contraindicated
- Alfuzosin + Bedaquiline Major
- Amiodarone + Bedaquiline Major
- Amitriptyline + Bedaquiline Major
- Amobarbital + Bedaquiline Major
- Anagrelide + Bedaquiline Major
Frequently asked questions
Can I take Amisulpride with Bedaquiline?
MediHelp rates the interaction as major. Amisulpride and Bedaquiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bedaquiline prolongs the QT interval, and amisulpride has a similar dose-related effect. Together they increase the possibility of serious ventricular arrhythmia, particularly given the long half-life of bedaquiline.
How serious is the interaction between Amisulpride and Bedaquiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative is available. Otherwise obtain a baseline ECG, monitor QTc regularly, and keep potassium, magnesium and calcium within normal ranges.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
