Drug interactions
Amobarbital + Bedaquiline
Severity: Major
Amobarbital and Bedaquiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital is a barbiturate that induces CYP3A4, the main enzyme clearing bedaquiline. Co-use can lower bedaquiline exposure and risk reduced antimycobacterial activity and treatment failure or resistance.
What this interaction means in plain words
Amobarbital and Bedaquiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Bedaquiline belongs to Anti Bacterial.
Why it happens
Barbiturate-mediated induction of CYP3A4 increases bedaquiline metabolism and lowers plasma concentrations.
What to do
Avoid combining with amobarbital; choose a non-inducing sedative or anticonvulsant. If unavoidable, monitor treatment response closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Bedaquiline
- Bedaquiline + Ziprasidone Contraindicated
- Alfuzosin + Bedaquiline Major
- Amiodarone + Bedaquiline Major
- Amisulpride + Bedaquiline Major
- Amitriptyline + Bedaquiline Major
- Anagrelide + Bedaquiline Major
Frequently asked questions
Can I take Amobarbital with Bedaquiline?
MediHelp rates the interaction as major. Amobarbital and Bedaquiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amobarbital is a barbiturate that induces CYP3A4, the main enzyme clearing bedaquiline. Co-use can lower bedaquiline exposure and risk reduced antimycobacterial activity and treatment failure or resistance.
How serious is the interaction between Amobarbital and Bedaquiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining with amobarbital; choose a non-inducing sedative or anticonvulsant. If unavoidable, monitor treatment response closely.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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