Drug interactions
Bedaquiline + Octreotide
Severity: Moderate
Bedaquiline and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval, so using them together may increase the risk of torsades de pointes. Octreotide is also associated with bradycardia, which can add to arrhythmic risk. The risk is greater with electrolyte disturbances or underlying cardiac disease.
What this interaction means in plain words
Bedaquiline and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bedaquiline belongs to Anti Bacterial; Octreotide belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain a baseline ECG and repeat during therapy, and correct potassium, magnesium and calcium abnormalities. Stop or reassess therapy if QTc becomes markedly prolonged or symptoms of arrhythmia appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Octreotide
Other interactions of Bedaquiline
- Bedaquiline + Ziprasidone Contraindicated
- Alfuzosin + Bedaquiline Major
- Amiodarone + Bedaquiline Major
- Amisulpride + Bedaquiline Major
- Amitriptyline + Bedaquiline Major
- Amobarbital + Bedaquiline Major
Frequently asked questions
Can I take Bedaquiline with Octreotide?
MediHelp rates the interaction as moderate. Bedaquiline and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QTc interval, so using them together may increase the risk of torsades de pointes. Octreotide is also associated with bradycardia, which can add to arrhythmic risk. The risk is greater with electrolyte disturbances or underlying cardiac disease.
How serious is the interaction between Bedaquiline and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat during therapy, and correct potassium, magnesium and calcium abnormalities. Stop or reassess therapy if QTc becomes markedly prolonged or symptoms of arrhythmia appear.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
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