Drug interactions
Bedaquiline + Salbutamol
Severity: Moderate
Bedaquiline and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bedaquiline prolongs the QT interval, and salbutamol may add to arrhythmic risk through hypokalemia and tachycardia. The risk is greater with other QT-prolonging drugs or electrolyte disturbances.
What this interaction means in plain words
Bedaquiline and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bedaquiline belongs to Anti Bacterial; Salbutamol belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta-2 agonist-induced hypokalemia increasing susceptibility.
What to do
Obtain baseline and periodic ECGs and keep potassium, magnesium and calcium normal during bedaquiline therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Other interactions of Bedaquiline
- Bedaquiline + Ziprasidone Contraindicated
- Alfuzosin + Bedaquiline Major
- Amiodarone + Bedaquiline Major
- Amisulpride + Bedaquiline Major
- Amitriptyline + Bedaquiline Major
- Amobarbital + Bedaquiline Major
Frequently asked questions
Can I take Bedaquiline with Salbutamol?
MediHelp rates the interaction as moderate. Bedaquiline and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bedaquiline prolongs the QT interval, and salbutamol may add to arrhythmic risk through hypokalemia and tachycardia. The risk is greater with other QT-prolonging drugs or electrolyte disturbances.
How serious is the interaction between Bedaquiline and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline and periodic ECGs and keep potassium, magnesium and calcium normal during bedaquiline therapy.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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