Drug interactions
Belinostat + Siponimod
Severity: Moderate
Belinostat and Siponimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Siponimod lowers circulating lymphocytes, and belinostat, a histone deacetylase inhibitor, can cause myelosuppression. Used together they may deepen immune suppression and raise the risk of serious infection.
What this interaction means in plain words
Belinostat and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belinostat belongs to Oncology; Siponimod belongs to Central Nervous System.
Why it happens
Additive immunosuppression through S1P receptor-mediated lymphocyte sequestration plus cytotoxic bone marrow suppression.
What to do
Monitor blood counts, particularly absolute lymphocyte and neutrophil counts, and watch for signs of infection throughout combined therapy. Consider whether siponimod should be paused during chemotherapy cycles.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Other interactions of Belinostat
- Apalutamide + Belinostat Moderate
- Belinostat + Gemfibrozil Moderate
Frequently asked questions
Can I take Belinostat with Siponimod?
MediHelp rates the interaction as moderate. Belinostat and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Siponimod lowers circulating lymphocytes, and belinostat, a histone deacetylase inhibitor, can cause myelosuppression. Used together they may deepen immune suppression and raise the risk of serious infection.
How serious is the interaction between Belinostat and Siponimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, particularly absolute lymphocyte and neutrophil counts, and watch for signs of infection throughout combined therapy. Consider whether siponimod should be paused during chemotherapy cycles.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
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