Drug interactions
Apalutamide + Belinostat
Severity: Moderate
Apalutamide and Belinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belinostat is eliminated mainly by UGT1A1 glucuronidation. Apalutamide induces UGT enzymes and might lower belinostat exposure, potentially reducing antitumor activity.
What this interaction means in plain words
Apalutamide and Belinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Belinostat belongs to Oncology.
Why it happens
Apalutamide induces UGT1A1, increasing the glucuronidation of belinostat.
What to do
Monitor for reduced response to belinostat when used together. Consider an alternative to apalutamide if clinically feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Belinostat
- Belinostat + Gemfibrozil Moderate
- Belinostat + Siponimod Moderate
Frequently asked questions
Can I take Apalutamide with Belinostat?
MediHelp rates the interaction as moderate. Apalutamide and Belinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belinostat is eliminated mainly by UGT1A1 glucuronidation. Apalutamide induces UGT enzymes and might lower belinostat exposure, potentially reducing antitumor activity.
How serious is the interaction between Apalutamide and Belinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response to belinostat when used together. Consider an alternative to apalutamide if clinically feasible.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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