Drug interactions
Belinostat + Gemfibrozil
Severity: Moderate
Belinostat and Gemfibrozil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil is an inhibitor of glucuronidation and may slow UGT1A1-mediated clearance of belinostat. Higher belinostat exposure may increase toxicity such as myelosuppression, hepatotoxicity and gastrointestinal effects.
What this interaction means in plain words
Belinostat and Gemfibrozil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Belinostat belongs to Oncology; Gemfibrozil belongs to Cardiovascular.
Why it happens
Gemfibrozil and its glucuronide inhibit UGT1A1, reducing belinostat glucuronidation.
What to do
If coadministration is unavoidable, consider the labeled reduced belinostat starting dose for UGT1A1 inhibitors. Monitor blood counts and liver tests.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Other interactions of Belinostat
- Apalutamide + Belinostat Moderate
- Belinostat + Siponimod Moderate
Frequently asked questions
Can I take Belinostat with Gemfibrozil?
MediHelp rates the interaction as moderate. Belinostat and Gemfibrozil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemfibrozil is an inhibitor of glucuronidation and may slow UGT1A1-mediated clearance of belinostat. Higher belinostat exposure may increase toxicity such as myelosuppression, hepatotoxicity and gastrointestinal effects.
How serious is the interaction between Belinostat and Gemfibrozil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If coadministration is unavoidable, consider the labeled reduced belinostat starting dose for UGT1A1 inhibitors. Monitor blood counts and liver tests.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
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