Drug interactions
Belladonna alkaloids + Indacaterol-glycopyrronium
Severity: Moderate
Belladonna alkaloids and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belladonna alkaloids such as hyoscyamine and atropine are antimuscarinic and add to the effects of inhaled glycopyrronium. Dry mouth, urinary retention, constipation, tachycardia and confusion may be more frequent.
What this interaction means in plain words
Belladonna alkaloids and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for anticholinergic toxicity, particularly in elderly patients or those with glaucoma or urinary obstruction. Avoid the combination in those conditions where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Belladonna alkaloids and Indacaterol-glycopyrronium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Indacaterol-glycopyrronium
Frequently asked questions
Can I take Belladonna alkaloids with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Belladonna alkaloids and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belladonna alkaloids such as hyoscyamine and atropine are antimuscarinic and add to the effects of inhaled glycopyrronium. Dry mouth, urinary retention, constipation, tachycardia and confusion may be more frequent.
How serious is the interaction between Belladonna alkaloids and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, particularly in elderly patients or those with glaucoma or urinary obstruction. Avoid the combination in those conditions where possible.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
