Drug interactions
Belladonna and opium + Clomipramine
Severity: Moderate
Belladonna and opium and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belladonna and opium combine an antimuscarinic with an opioid, and clomipramine adds both anticholinergic and sedative effects. The combination can cause sedation, respiratory depression, constipation, urinary retention and confusion.
What this interaction means in plain words
Belladonna and opium and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects and additive CNS and respiratory depression.
What to do
Monitor sedation, respiratory rate, bowel and bladder function. Use the lowest effective doses and avoid additional CNS depressants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Belladonna and opium with Clomipramine?
MediHelp rates the interaction as moderate. Belladonna and opium and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belladonna and opium combine an antimuscarinic with an opioid, and clomipramine adds both anticholinergic and sedative effects. The combination can cause sedation, respiratory depression, constipation, urinary retention and confusion.
How serious is the interaction between Belladonna and opium and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, respiratory rate, bowel and bladder function. Use the lowest effective doses and avoid additional CNS depressants.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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