Drug interactions
Belladonna and opium + Desflurane
Severity: Moderate
Belladonna and opium and Desflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The opium component adds opioid sedation and respiratory depression to desflurane and reduces the anesthetic concentration required. The belladonna alkaloids add anticholinergic effects such as tachycardia and reduced gut motility. Overall there is greater risk of respiratory depression, hypotension and delayed emergence.
What this interaction means in plain words
Belladonna and opium and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression from opioid action, with opioid-related reduction in minimum alveolar concentration.
What to do
Reduce desflurane concentration according to clinical response and monitor respiratory rate, oxygenation and heart rate. Have opioid reversal and airway equipment ready.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Frequently asked questions
Can I take Belladonna and opium with Desflurane?
MediHelp rates the interaction as moderate. Belladonna and opium and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The opium component adds opioid sedation and respiratory depression to desflurane and reduces the anesthetic concentration required. The belladonna alkaloids add anticholinergic effects such as tachycardia and reduced gut motility. Overall there is greater risk of respiratory depression, hypotension and delayed emergence.
How serious is the interaction between Belladonna and opium and Desflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce desflurane concentration according to clinical response and monitor respiratory rate, oxygenation and heart rate. Have opioid reversal and airway equipment ready.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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