Drug interactions
Belladonna and opium + Dicyclomine
Severity: Moderate
Belladonna and opium and Dicyclomine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belladonna and opium combines an antimuscarinic with an opioid. Adding dicyclomine increases anticholinergic effects, and with the opioid it raises the risk of severe constipation, urinary retention and ileus, plus sedation.
What this interaction means in plain words
Belladonna and opium and Dicyclomine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects on gut and bladder, with opioid-induced reduction in gastrointestinal motility.
What to do
Monitor bowel function, urinary output and sedation. Avoid use in patients with obstruction or ileus.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Frequently asked questions
Can I take Belladonna and opium with Dicyclomine?
MediHelp rates the interaction as moderate. Belladonna and opium and Dicyclomine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belladonna and opium combines an antimuscarinic with an opioid. Adding dicyclomine increases anticholinergic effects, and with the opioid it raises the risk of severe constipation, urinary retention and ileus, plus sedation.
How serious is the interaction between Belladonna and opium and Dicyclomine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function, urinary output and sedation. Avoid use in patients with obstruction or ileus.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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