Drug interactions
Belladonna and opium + Haloperidol
Severity: Moderate
Belladonna and opium and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This combination adds opioid-related sedation and respiratory depression from opium to haloperidol's sedative effect, and belladonna adds anticholinergic burden. Constipation, urinary retention, confusion and hypotension may be worsened.
What this interaction means in plain words
Belladonna and opium and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression plus additive antimuscarinic effects.
What to do
Use the lowest effective doses and monitor sedation, respiratory rate, bowel and bladder function. Counsel patients to avoid alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Belladonna and opium with Haloperidol?
MediHelp rates the interaction as moderate. Belladonna and opium and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This combination adds opioid-related sedation and respiratory depression from opium to haloperidol's sedative effect, and belladonna adds anticholinergic burden. Constipation, urinary retention, confusion and hypotension may be worsened.
How serious is the interaction between Belladonna and opium and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation, respiratory rate, bowel and bladder function. Counsel patients to avoid alcohol and other sedatives.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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