Drug interactions
Belladonna and opium + Indacaterol-glycopyrronium
Severity: Moderate
Belladonna and opium and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belladonna and opium combines an antimuscarinic with an opioid, so it adds to the anticholinergic burden of glycopyrronium. Constipation, urinary retention and ileus risk are increased, along with sedation from the opioid.
What this interaction means in plain words
Belladonna and opium and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects, with opioid-related reduction in gastrointestinal and urinary motility.
What to do
Monitor bowel and bladder function and watch for sedation or confusion. Use the lowest effective dose and avoid in patients with obstruction or narrow-angle glaucoma.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Frequently asked questions
Can I take Belladonna and opium with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Belladonna and opium and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belladonna and opium combines an antimuscarinic with an opioid, so it adds to the anticholinergic burden of glycopyrronium. Constipation, urinary retention and ileus risk are increased, along with sedation from the opioid.
How serious is the interaction between Belladonna and opium and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel and bladder function and watch for sedation or confusion. Use the lowest effective dose and avoid in patients with obstruction or narrow-angle glaucoma.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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