Drug interactions
Belladonna and opium + Ipratropium
Severity: Minor
Belladonna and opium and Ipratropium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belladonna alkaloids have antimuscarinic activity, so combining them with ipratropium can add to anticholinergic effects such as dry mouth, urinary retention, constipation and blurred vision. Because inhaled ipratropium is poorly absorbed, the effect is generally modest at usual doses, but opium in the suppository adds constipating and CNS depressant effects.
What this interaction means in plain words
Belladonna and opium and Ipratropium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive antagonism of muscarinic receptors.
What to do
Monitor for urinary retention, constipation and dry mouth, especially in older patients or those with prostatic hypertrophy or glaucoma. Reduce the belladonna dose or stop it if anticholinergic symptoms develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ipratropium
- Aclidinium + Ipratropium Moderate
- Benztropine + Ipratropium Moderate
- Bethanechol + Ipratropium Moderate
- Cevimeline + Ipratropium Moderate
- Chlorpromazine + Ipratropium Moderate
- Clomipramine + Ipratropium Moderate
Frequently asked questions
Can I take Belladonna and opium with Ipratropium?
MediHelp rates the interaction as minor. Belladonna and opium and Ipratropium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Belladonna alkaloids have antimuscarinic activity, so combining them with ipratropium can add to anticholinergic effects such as dry mouth, urinary retention, constipation and blurred vision. Because inhaled ipratropium is poorly absorbed, the effect is generally modest at usual doses, but opium in the suppository adds constipating and CNS depressant effects.
How serious is the interaction between Belladonna and opium and Ipratropium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation and dry mouth, especially in older patients or those with prostatic hypertrophy or glaucoma. Reduce the belladonna dose or stop it if anticholinergic symptoms develop.
What other medicines interact with Ipratropium?
MediHelp also lists interactions of Ipratropium with, for example, Aclidinium, Benztropine, Bethanechol. The full list is on the Ipratropium page.
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