Drug interactions
Cevimeline + Ipratropium
Severity: Moderate
Cevimeline and Ipratropium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is a muscarinic agonist used for dry mouth and ipratropium blocks muscarinic receptors, so each may reduce the effect of the other. Ipratropium can also worsen dry mouth and reduce the benefit of cevimeline.
What this interaction means in plain words
Cevimeline and Ipratropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cevimeline belongs to Miscellaneous; Ipratropium belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Monitor for reduced salivary response to cevimeline and for worsened respiratory control. Consider whether anticholinergic bronchodilator therapy can be minimized or replaced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium
- Aclidinium + Ipratropium Moderate
- Benztropine + Ipratropium Moderate
- Bethanechol + Ipratropium Moderate
- Chlorpromazine + Ipratropium Moderate
- Clomipramine + Ipratropium Moderate
- Clozapine + Ipratropium Moderate
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Cevimeline with Ipratropium?
MediHelp rates the interaction as moderate. Cevimeline and Ipratropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cevimeline is a muscarinic agonist used for dry mouth and ipratropium blocks muscarinic receptors, so each may reduce the effect of the other. Ipratropium can also worsen dry mouth and reduce the benefit of cevimeline.
How serious is the interaction between Cevimeline and Ipratropium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced salivary response to cevimeline and for worsened respiratory control. Consider whether anticholinergic bronchodilator therapy can be minimized or replaced.
What other medicines interact with Ipratropium?
MediHelp also lists interactions of Ipratropium with, for example, Aclidinium, Benztropine, Bethanechol. The full list is on the Ipratropium page.
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