Drug interactions
Chlorpromazine + Ipratropium
Severity: Moderate
Chlorpromazine and Ipratropium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine has notable anticholinergic activity, so combined use can increase dry mouth, constipation, urinary retention, blurred vision and sedation. Added anticholinergic load may also worsen confusion in older patients.
What this interaction means in plain words
Chlorpromazine and Ipratropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Ipratropium belongs to Respiratory.
Why it happens
Additive muscarinic receptor blockade.
What to do
Monitor for anticholinergic adverse effects and review the need for both agents in elderly patients. Reduce the dose or choose a less anticholinergic antipsychotic if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium
- Aclidinium + Ipratropium Moderate
- Benztropine + Ipratropium Moderate
- Bethanechol + Ipratropium Moderate
- Cevimeline + Ipratropium Moderate
- Clomipramine + Ipratropium Moderate
- Clozapine + Ipratropium Moderate
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Ipratropium?
MediHelp rates the interaction as moderate. Chlorpromazine and Ipratropium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine has notable anticholinergic activity, so combined use can increase dry mouth, constipation, urinary retention, blurred vision and sedation. Added anticholinergic load may also worsen confusion in older patients.
How serious is the interaction between Chlorpromazine and Ipratropium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and review the need for both agents in elderly patients. Reduce the dose or choose a less anticholinergic antipsychotic if symptoms develop.
What other medicines interact with Ipratropium?
MediHelp also lists interactions of Ipratropium with, for example, Aclidinium, Benztropine, Bethanechol. The full list is on the Ipratropium page.
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