Drug interactions
Belladonna and opium + Lurasidone
Severity: Moderate
Belladonna and opium and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The opium component is an opioid and belladonna is anticholinergic. Together with lurasidone, additive sedation, respiratory depression, hypotension and anticholinergic effects may occur.
What this interaction means in plain words
Belladonna and opium and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid and antipsychotic effects, with added anticholinergic burden.
What to do
Use the lowest effective doses and monitor sedation, respiratory rate and anticholinergic effects such as constipation or urinary retention. Counsel patients to avoid alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Belladonna and opium with Lurasidone?
MediHelp rates the interaction as moderate. Belladonna and opium and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The opium component is an opioid and belladonna is anticholinergic. Together with lurasidone, additive sedation, respiratory depression, hypotension and anticholinergic effects may occur.
How serious is the interaction between Belladonna and opium and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation, respiratory rate and anticholinergic effects such as constipation or urinary retention. Counsel patients to avoid alcohol and driving.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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