Drug interactions
Belladonna and opium + Perphenazine
Severity: Major
Belladonna and opium and Perphenazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination adds anticholinergic effects from belladonna and perphenazine to CNS and respiratory depression from opium and perphenazine. This can produce marked sedation, constipation, urinary retention and confusion, and in vulnerable patients respiratory depression.
What this interaction means in plain words
Belladonna and opium and Perphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS/respiratory depression from opioid and phenothiazine plus additive antimuscarinic effects.
What to do
Use the lowest effective doses and monitor sedation, respiratory rate and bowel and bladder function. Avoid alcohol and other CNS depressants, and consider alternatives in elderly or respiratory-compromised patients.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Belladonna and opium with Perphenazine?
MediHelp rates the interaction as major. Belladonna and opium and Perphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The combination adds anticholinergic effects from belladonna and perphenazine to CNS and respiratory depression from opium and perphenazine. This can produce marked sedation, constipation, urinary retention and confusion, and in vulnerable patients respiratory depression.
How serious is the interaction between Belladonna and opium and Perphenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation, respiratory rate and bowel and bladder function. Avoid alcohol and other CNS depressants, and consider alternatives in elderly or respiratory-compromised patients.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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