Drug interactions
Belladonna and opium + Pregabalin
Severity: Major
Belladonna and opium and Pregabalin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids combined with pregabalin produce additive sedation and can cause serious respiratory depression. Regulators have warned of increased respiratory depression risk when gabapentinoids are used with opioids.
What this interaction means in plain words
Belladonna and opium and Pregabalin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from opioid effects plus pregabalin's sedative effects.
What to do
Use the lowest effective doses for the shortest duration and monitor for sedation and slowed breathing. Consider dose reduction of either agent, especially in elderly patients or those with respiratory disease.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pregabalin
Frequently asked questions
Can I take Belladonna and opium with Pregabalin?
MediHelp rates the interaction as major. Belladonna and opium and Pregabalin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with pregabalin produce additive sedation and can cause serious respiratory depression. Regulators have warned of increased respiratory depression risk when gabapentinoids are used with opioids.
How serious is the interaction between Belladonna and opium and Pregabalin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest duration and monitor for sedation and slowed breathing. Consider dose reduction of either agent, especially in elderly patients or those with respiratory disease.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Pregabalin page.
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