Drug interactions
Amobarbital + Pregabalin
Severity: Major
Amobarbital and Pregabalin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pregabalin combined with a barbiturate can produce additive drowsiness, impaired psychomotor function and respiratory depression. Risk is higher in the elderly and in patients with compromised respiratory function.
What this interaction means in plain words
Amobarbital and Pregabalin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Pregabalin belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects through pharmacodynamic synergism.
What to do
Use the lowest effective doses and monitor sedation and respiratory status; counsel patients to avoid driving.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Pregabalin
Frequently asked questions
Can I take Amobarbital with Pregabalin?
MediHelp rates the interaction as major. Amobarbital and Pregabalin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pregabalin combined with a barbiturate can produce additive drowsiness, impaired psychomotor function and respiratory depression. Risk is higher in the elderly and in patients with compromised respiratory function.
How serious is the interaction between Amobarbital and Pregabalin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory status; counsel patients to avoid driving.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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