Drug interactions
Brexanolone + Pregabalin
Severity: Major
Brexanolone and Pregabalin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexanolone causes excessive sedation and sudden loss of consciousness, and pregabalin adds further CNS depression. Concomitant CNS depressants may increase the risk of respiratory depression and profound sedation.
What this interaction means in plain words
Brexanolone and Pregabalin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depressant effects (pharmacodynamic synergism).
What to do
During the brexanolone infusion, monitor continuously with pulse oximetry and sedation assessment. Consider holding or reducing the pregabalin dose if sedation occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pregabalin
Frequently asked questions
Can I take Brexanolone with Pregabalin?
MediHelp rates the interaction as major. Brexanolone and Pregabalin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brexanolone causes excessive sedation and sudden loss of consciousness, and pregabalin adds further CNS depression. Concomitant CNS depressants may increase the risk of respiratory depression and profound sedation.
How serious is the interaction between Brexanolone and Pregabalin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: During the brexanolone infusion, monitor continuously with pulse oximetry and sedation assessment. Consider holding or reducing the pregabalin dose if sedation occurs.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
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